Western sanctions against Russia over its role in Ukraine are aimedat forcing regime change in Moscow, Foreign Minister Sergei Lavrov says.
Speaking to foreign policy advisers in Moscow, Mr Lavrov referred to calls for sanctions "that will destroy the economy and cause public protests".
On Thursday, President Vladimir Putin said Moscow must guard against a "colour revolution".
Russia denies arming Ukrainian rebels or sending Russian troops there.
Western sanctions were first imposed when Russia annexed Ukraine's region of Crimea in March following a controversial referendum.
Further measures have been added since, targeting senior Russian officials as well as defence firms, banks and the country's oil industry.
On Thursday, referring to popular uprisings in former Soviet countries including Ukraine and Georgia, President Putin said the world could see "what tragic consequences the wave of the so-called colour revolutions has led to".
Ukraine's 2004 pro-Western uprising became known as the Orange Revolution, while Georgia's Rose Revolution took place in 2008.
"We have to do all that is needed to ensure that similar things never happen in Russia," Mr Putin said.
Addressing the advisory Foreign and Defence Policy Council in Moscow on Saturday, his foreign minister said: "As for the concept behind to the use of coercive measures, the West is making clear it does not want to force Russia to change policy but wants to secure regime change."
"Public figures in Western countries say there is a need to impose sanctions that will destroy the economy and cause public protests," Mr Lavrov said without naming any Western officials.